HemaVision® is a series of CE marked in vitro diagnostic (IVD) tests for fast and sensitive detection of chromosomal translocations associated with leukemia. The tests are fast one-day RT-PCR screening tests, capable of analysing for up to 28 translocations and more than 145 clinical relevant translocation breakpoints in a single test.
The starting material for the HemaVision® tests is total RNA extracted from whole blood or bone marrow. The tests can be performed as a screening for 28 translocations or 7 translocations. Single translocation tests are also available.
RT-qPCR HemaVision® kit is screening made simple and precise. With clear benefits for patients and professionals alike.
HemaVision®-28Q is a RT-qPCR based assay (Reverse Transcription followed by Real-Time PCR) for detection of leukemia associated fusion gene transcripts in total RNA from whole blood or bone marrow samples.
HemaVision®-28Q provides a rapid screening for 28 translocations with more than 145 clinically relevant chromosomal breakpoints. Both common and rare translocation breakpoints and alternative splice variants are detected in only 4 hours from RNA extraction.
The kit screens for rare translocations and fusion products, which cannot be detected with other commercial screening kits.
28 translocations
del1(p32) (STIL-TAL1)
t(1;11) (p32;q23) (KMT2A-EPS15)
t(1;11) (q21;q23) (KMT2A-MLLT11)
t(1;19) (q23;p13) (TCF3-PBX1)
t(3;5) (q25;q34) (NPM1-MLF1)
t(3;21) (q26;q22) (RUNX1-MDS1/EVI1)
t(4;11) (q21;q23) (KMT2A-AFF1)
t(5;12) (q33;p13) (ETV6-PDGFRB)
t(5;17) (q35;q21) (NPM1-RARA)
t(6;9) (p23;q34) (DEK-NUP214)
t(6;11) (q27;q23) (KMT2A-AFON)
t(8;21) (q22;q22) (RUNX1-RUNX1T1)
t(9;9) (q34;q34) (SET-NUP214)
t(9;11) (p22;q23) (KMT2A-MLLT3)
t(9;12) (q34;p13) (ETV6-ABL1)
t(9,22) (q34;q11) (BCR-ABL1)
t(10;11) (p12;q23) (KMT2A-MLLT10)
t(11;17) (q23;q21) (KMT2A-MLLT6)
t(11;17) (q23;q21) (ZBTB16-RARA)
t(11;19) (q23;p13.1) (KMT2A-ELL)
t(11;19) (q23;p13.3) (KMT2A-MLLT1)
t(12;21) (p13;q22) (ETV6-RUNX1)
t(12;22) p13;q11) (ETV6-MN1)
t(15;17) (q24;q21) (PML-RARA)
inv(16) (p13;q22) (CBFB-MYH11)
t(16;21) (p11;q22) (FUS-ERG)
t(17;19) (q22;p13) (TCF3-HLF)
t(X;11) (q13;q23) (KMT2A-FOXO4)
Catalogue number HV01-28Q
RT-qPCR HemaVision® kit for the screening and detection of 28 chromosome translocations with more than 145 clinically relevant chromosomal breakpoints in just 4 hours. Supplied in three types of qPCR tubes: WRP, WLP or FRP. Contain material for 12 tests.
